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Lab-on-paper strip: Small, inexpensive platform for diagnosing tropical fevers


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Lab-on-paper strip: Small, inexpensive platform for diagnosing tropical fevers

The ongoing COVID-19 pandemic has shown how foremost it’s miles to have tools that might perhaps hasty diagnose viral infectious diseases. With the exception of for the SARS-CoV-2 virus, which has currently taken the highlight, the zika, dengue, and chikungunya viruses have also change into foremost threats to human smartly being in quite loads of substances of the enviornment, notably in tropical worldwide locations. All three viruses are transmitted by mosquitoes and motive diseases which have identical signs, making early prognosis notably refined with out complex molecular diagnostic equipment.

In a fresh effort to fabricate the prognosis of these mosquito-borne diseases sooner and less complicated, a group of scientists, led by Professor Min-Gon Kim from the Gwangju Institute of Science and Technology in Korea, have developed a compact, completely computerized, and much less expensive application that might perhaps determine the presence of these viruses from a blood serum sample. The instrument, named LAMDA (stands for lab-on-paper for all-in-one molecular diagnostics) by the scientists, is that if truth be told a mini laboratory on a paper strip—vaguely paying homage to over-the-counter being pregnant assessments.

LAMDA performs the total steps of a worn nucleic acid take a look at (a molecular diagnostic take a look at), particularly sampling, extraction, amplification, and detection of the target viral RNA, with out exterior intervention at any intermediate step. To make exhaust of LAMDA, one has to merely role a tumble of blood serum and some drops of distilled water on two pads. The liquids naturally circulate thru the paper strip horizontally and attain the defective of a exiguous vertical stack of layers that extracts the total RNA from the sample and multiplies any present viral RNA of the three diseases.

The tip layer of the vertical stack comprises person “response” patches, every designed to detect one amongst the three diseases. After the RNA is extracted, it flows as a lot as the end layer, the put “LAMP (Loop-mediated isothermal amplification)” reactions motive the fluorescent indicators on a patch to change into gloomy if its target viral RNA is pronounce in the sample.

In this come, LAMDA can accurately diagnose any of the three mosquito-borne diseases in no longer as a lot as an hour. All in favour of the outcomes, that are published in Elsevier’s Biosensors and Bioelectronics, Prof Kim remarks: “We have that with minor adjustments, a lot like a transportable system to protect response temperature at 65°C and a technique to detect the fluorescence exchange with a smartphone, the proposed all-in-one paper chip can change into a transportable, low-fee, user-good, at ease, and explicit nucleic acid take a look at platform with gigantic doable in level-of-care diagnostics.

LAMDA might perhaps well also presumably be an very effective choice for resource-restricted clinics and hospitals, that are sadly current amongst worldwide locations most tormented by mosquito-borne diseases. It could perhaps well also bolster future overview in the realm of diagnostics for other infectious diseases. “We completely hope that our come and achievements with LAMDA will be important to attain overview and vogue of on-negate clinical diagnostic tools,” Prof Kim concludes.

Per chance, a generation of lawful and excessive-utility pocket diagnostic tools is on the horizon!



Authors: Youngung Seok (1), Bhagwan S. Batule (2,3), and Min-Gon Kim (2*)


Title of usual paper: Lab-on-paper for all-in-one molecular diagnostics (LAMDA) of zika, dengue, and chikungunya virus from human serum


Journal: Biosensors and Bioelectronics


DOI: 10.1016/j.bios.2020.112400


1. Division of Mechanical Engineering and Applied Mechanics, School of Engineering and Applied Science, University of Pennsylvania

2. Division of Chemistry, School of Physics and Chemistry, Gwangju Institute of Science and Technology (GIST)

3. Boditech Med Inc.

*Corresponding author’s email:

About Gwangju Institute of Science and Technology (GIST)

Gwangju Institute of Science and Technology (GIST) is a overview-oriented college located in Gwangju, South Korea. One of essentially the most prestigious colleges in South Korea, it became founded in 1993. The college targets to receive a powerful overview atmosphere to spur traits in science and know-how and to promote collaboration between foreign and domestic overview programs. With its motto, “A Proud Creator of Future Science and Technology,” the college has consistently received one amongst the absolute best college rankings in Korea.

Referring to the author

Dr. Min-Gon Kim is a Professor of the Division of Chemistry on the Gwangju Institute of Science and Technology. His overview community specializes in the attain of biosensors and nanobiomaterials by the combination of bio-organic and inorganic materials. Dr. Kim’s Lab is developing rapid, excessive-sensitivity and life like biosensors for diagnostics and meals security. One other level of curiosity put is biomolecule immobilization and bio-nanoprobe syntheses. In particular, Kim’s overview community has executed gigantic success in the attain of lab-on paper devices, LSPR, colorimetric, FRET, and CRET biosensors to detect target analytes.

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Published on: Sep 07, 2020

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